中图分类号：TP391 文献标志码：A DOI: 10.16157/j.issn.0258-7998.244946 中文引用格式： 赵欢欢，李颜娥，武斌，等. 基于拓扑结构的度量学习与拓扑传播的miRNA-疾病关联预测算法[J]. 电子技术应用，2024，50(9)：67-72. 英文引用格式： Zhao Huanhuan，Li Yan′e，Wu Bin，et al. Topology-based metric learning and topology propagation algorithm for miRNA-disease association prediction[J]. Application of Electronic Technique，2024，50(9)：67-72.
Topology-based metric learning and topology propagation algorithm for miRNA-disease association prediction
Zhao Huanhuan1，Li Yan′e1，Wu Bin1，Chi Fang′ai2
1.College of Mathematics and Computer Science， Zhejiang A & F University； 2.School of Landscape Architecture， Zhejiang A & F University
Abstract： Mutations and abnormal expressions of miRNA can potentially lead to various diseases. Hence, predicting the latent correlation between miRNA and diseases holds significant importance for the advancement of clinical medicine and drug research. The topology structure constitutes a crucial component of miRNA-disease prediction algorithms. However, the current algorithms inadequately leverage the topological structure, resulting in suboptimal predictive outcomes. Simultaneously, effectively integrating multi-source data is a current research trend. In response to the aforementioned issues, this paper proposes an adaptive algorithm for fusing heterogeneous node structure information (MMTP). MMTP enhances miRNA-disease prediction accuracy by adaptively integrating heterogeneous node structure information through the utilization of first-order neighbors and metapath-induced network learning of structural features, employing metric learning and topology propagation. Results from a 5-fold cross-validation experiment demonstrate that MMTP achieves Area Under the Curve (AUC) of receiver operating characteristic values of 94.81 on the HMDD v3.2 datasets, surpassing other models. Moreover, in a case study focused on renal cancer, all of the top 30 miRNAs predicted by the model are confirmed. The aforementioned research confirms the efficacy of the proposed MMTP model in predicting miRNA-disease correlations.
Key words : deep learning；miRNA-disease association；metric learning；topology structure
